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PLAVIX™ Sanofi/Bristol-Myers Squibb Clopidogrel Bisulfate Platelet Aggregation Inhibitor Action And Clinical Pharmacology: Mechanism of Action: The role of platelets in the pathophysiology of atherosclerotic disease and thrombotic events has been established. Long-term prophylactic use of antiplatelet drugs has shown consistent benefit in the prevention of ischemic stroke, myocardial infarction and vascular death in patients at increased risk of such outcomes, including those with established atherosclerosis or a history of atherothrombosis….

PLATINOL®-AQ Bristol Cisplatin Antineoplastic Caution: Cisplatin is a potent drug and should be used only by physicians experienced with cancer chemotherapeutic drugs (see Warnings and Precautions). Blood counts as well as renal and hepatic function tests should be taken regularly. Discontinue the drug if abnormal depression of bone marrow or abnormal renal or hepatic function is seen. Action And Clinical Pharmacology: Cisplatin has biochemical properties similar to those of bifunctional…

PLENDIL® Astra Felodipine Antihypertensive Agent Action And Clinical Pharmacology: Felodipine is a calcium ion influx inhibitor (calcium channel blocker). Felodipine is a member of the dihydropyridine class of calcium channel blockers. Mechanism of Action: The therapeutic effect of this group of drugs is believed to be related to their specific cellular action of selectively inhibiting transmembrane influx of calcium ions into cardiac muscle and vascular smooth muscle. The contractile processes…

PNEUMOCOCCAL POLYSACCHARIDE VACCINE PNEUMO 23™ Connaught Active Immunizing Agent Action And Clinical Pharmacology: Pneumococcal polysaccharide vaccine, Pneumo 23 is a capsular polysaccharide vaccine against disease caused by 23 of the most common types of S. pneumoniae (pneumococcus). Approximately 90% of cases of pneumococcal bacteremia and meningitis are caused by these 23 types. Although the overall incidence of pneumococcal infections in Canada is not known, invasive disease is most common in…

PHYLLOCONTIN® PHYLLOCONTIN®-350 Purdue Frederick Aminophylline Bronchodilator Action And Clinical Pharmacology: Aminophylline is the ethylenediamine salt of theophylline. The pharmacodynamics of Phyllocontin and Phyllocontin-350 tablets are a function of theophylline blood levels. Theophylline is a xanthine structurally related to theobromine and caffeine. As with other xanthine derivatives, the precise mechanism of action of theophylline has not been determined. Theophylline stimulates the CNS and skeletal muscles, stimulates cardiac muscle, relaxes certain smooth…

PIPORTIL L4® Rh´ne-Poulenc Rorer Pipotiazine Palmitate Antipsychotic Action And Clinical Pharmacology: Pipotiazine palmitate is the palmitic ester of pipotiazine, a piperidine phenothiazine with antipsychotic properties and weak sedative activity with prolonged duration of action. The onset of action appears usually within the first 2 to 3 days after injection and the effects of the drug on psychotic symptoms are significant within 1 week. Improvement in symptomatology lasts from 3 to…

PIPRACIL® Wyeth-Ayerst Piperacillin Sodium Antibiotic Action And Clinical Pharmacology: Piperacillin is a third-generation, broad-spectrum, semisynthetic penicillin. Piperacillin is bactericidal and exerts its antibacterial action by inhibiting both septum and cell wall synthesis in the bacterial cell. The bactericidal action of b-lactam antibiotics is related to their ability to reach and bind target proteins, the penicillin sensitive enzymes within the cytoplasmic membranes of the bacteria. These enzymes are involved in reactions…

PLAQUENIL® Sanofi Hydroxychloroquine Sulfate Anti-inflammatory – Antimalarial Action And Clinical Pharmacology: Hydroxychloroquine has been beneficial for a high percentage of patients with rheumatoid arthritis and lupus erythematosus, especially chronic discoid lupus. The exact mode of action in controlling these diseases is unknown. The action of this compound against malarial parasites is similar to that of chloroquine phosphate. Indications And Clinical Uses: For the treatment of rheumatoid arthritis, and discoid and…

pHisoHex® Sanofi Hexachlorophene Antibacterial – Skin Cleanser Description: pHisoHex is an antibacterial sudsing emulsion. It contains entsufon (sodium octylphenoxyethoxyethyl ether sulfonate), lanolin cholesterols, petrolatum and 3% hexachlorophene on a total weight basis. It is a colloidal dispersion of the active ingredients in a stable emulsion. Entsufon is a synthetic detergent which is effective in many kinds of water – hard or soft, cold or hot – and under acid as…

PHOSPHATE-NOVARTIS Novartis Pharmaceuticals Sodium Acid Phosphate Hypercalciuria – Electrolyte Replenisher Indications And Clinical Uses: Hypercalciuria, electrolyte replenisher. Contra-Indications: Do not use this medication if hyperphosphatemia is present or in the presence of severe impairment of renal function (less than 30% of normal). Manufacturers’ Warnings In Clinical States: Use carefully in patients with cardiac disease treated with digitalis and in conditions where high potassium concentration may be encountered such as: adrenal…