You searched for : 'O'

VIQUIN FORTE® ICN Hydroquinone – Glycolic Acid Depigmentation Agent – Moisturizer Action And Clinical Pharmacology: Hyperpigmentation refers to the brown skin spots caused by an excess of the skin pigment melanin in certain areas. It can be hereditary as are freckles, caused by sun damage, occur with increasing age, or be related to pregnancy or the use of oral contraceptives. Hyperpigmentation usually develops gradually and increases with sun exposure. Skin…

VIDEX™ Bristol Didanosine Antiretroviral Agent Action And Clinical Pharmacology: Didanosine is a synthetic, purine nucleoside analogue of deoxyadenosine, active against the Human Immunodeficiency Virus (HIV). Didanosine inhibits the in vitro replication of HIV in human primary cells cultures and in established cell lines. The active antiviral metabolite, dideoxyadenosine-triphosphate (ddATP), is formed in several steps by phosphorylation of didanosine by cellular enzymes. Inhibition of HIV reverse transcriptase by ddATP is through…

VINCRISTINE SULFATE INJECTION USP Faulding Antineoplastic Action And Clinical Pharmacology: The mode of action of vincristine has not been completely delineated. Evidence is available from in vitro studies that vincristine inhibits spindle formation and is associated with the reversible binding of vincristine to spindle proteins in the S phase. Vincristine has also been found to interfere with RNA synthesis. It has also been shown to stop cell reproduction in metaphase,…

VIOFORM® HYDROCORTISONE Novartis Pharmaceuticals Clioquinol – Hydrocortisone Antibacterial – Antifungal – Topical Corticosteroid Action And Clinical Pharmacology: Clioquinol, the antimicrobial component of Vioform Hydrocortisone, is active against a broad spectrum of pathogenic microorganisms, including fungi (e.g., Candida, Microsporum, Trichophyton) and gram-positive bacteria (e.g., Staphylococci). Clioquinol has only a slight inhibitory effect on gram-negative bacteria. Clioquinol exerts a bacteriostatic, rather than a bactericidal action. Hydrocortisone is a mild glucocorticoid with an…

VIOFORM® Novartis Pharmaceuticals Clioquinol Antibacterial – Antifungal Action And Clinical Pharmacology: Clioquinol is active against a broad spectrum of pathogenic microorganisms, including fungi (e.g., Candida, Microsporum, Trichophyton) and gram-positive bacteria (e.g., Staphylococci). Clioquinol has only a slight inhibitory effect on gram-negative bacteria. Clioquinol exerts a bacteriostatic, rather than a bactericidal action. The antibacterial and antifungal properties of clioquinol have long been clinically established. Topically, clioquinol has demonstrated effectiveness in secondary…

VIBRA-TABS™ C-PAK™ Pfizer Doxycycline Hyclate Antibiotic Indications And Clinical Uses: In adult patients with urethritis, cervicitis and vaginitis with a positive test for C. trachomatis and/or U. urealyticum, clinical resolution and absence of detectable organisms have only been observed at completion of oral therapy with doxycycline. Relapses or reinfection can occur. In these cases, limited data suggest that some patients may derive clinical benefit from the oral administration of doxycycline…

VIBRA-TABS™ Pfizer Doxycycline Hyclate Antibiotic Action And Clinical Pharmacology: Doxycycline hyclate is a broad-spectrum antibiotic and is active against a wide range of gram-negative and gram-positive organisms. Doxycycline exerts its bacteriostatic effect by the inhibition of protein synthesis. Indications And Clinical Uses: For the treatment of: Pneumonia: single and multilobe pneumonia and bronchopneumonia due to susceptible strains of S. pneumoniae (formerly D. pneumoniae) and other Streptococci, Staphylococcus, H. influenzae and…

VERMOX® Janssen-Ortho Mebendazole Anthelmintic Action And Clinical Pharmacology: Mebendazole induces in vitro and in vivo inhibition of the glucose uptake by parasitic helminths; this is associated with glycogen depletion and a decrease in the generation of ATP, leading to inhibition of larval development. Mebendazole is poorly absorbed after oral administration. At the normal anthelmintic dosage, the bioavailability is poor due to a combination of high first-pass metabolism and the very…

VERSED® Roche Midazolam Premedicant – Sedative – Anesthetic Action And Clinical Pharmacology: General: Adult and Pediatric: I.V. midazolam has been associated with respiratory depression and respiratory arrest, especially when used for sedation in noncritical care settings. In some cases, where this was not recognized promptly and treated effectively, death or hypoxic encephalopathy has resulted. I.V. midazolam should be used only in hospital or ambulatory care settings that provide for continuous…

VESANOID™ Roche All-trans Retinoic Acid Tretinoin Differentiation Inducing Agent Caution: All-trans retinoic acid should be administered to patients with APL only under the strict supervision of a physician who is experienced in the treatment of hematological/oncological diseases. Action And Clinical Pharmacology: All-trans retinoic acid is a natural metabolite of retinol and belongs to the class of compounds known as retinoids, which are structurally related to vitamin A and comprise natural…