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PANCREASE® PANCREASE® MT Janssen-Ortho Pancrelipase Digestant Action And Clinical Pharmacology: The enteric-coated microtablets resist gastric inactivation and deliver predictable, high levels of biologically active pancreatic enzymes (lipase, amylase, and protease) into the duodenum. The enzymes catalyze the hydrolysis of fats into glycerol and fatty acids, proteins into proteoses and derived substances, and starch into dextrins and sugars. Pharmacokinetics: Absorption: The intestinal bioavailability of Pancrease MT 16 capsules was determined, in…

PANOCAINE® Hoechst Marion Roussel Benzocaine – Tetracaine HCl Oral Topical Anesthetic Action And Clinical Pharmacology: Panocaine is a local anesthetic of the ester type which rapidly produces surface anesthesia following application to the mucosa of the oral cavity in clinical dentistry. Panocaine has a short duration of action and is ineffective when applied to intact skin. Indications And Clinical Uses: For use in the oral cavity for minimizing the pain…

PANECTYL® Rhône-Poulenc Rorer Trimeprazine Tartrate Antipruritic – Antihistamine Action And Clinical Pharmacology: Trimeprazine is a propylamino phenothiazine derivative with reduced central activity and enhanced antihistaminic and antipruritic effects. It is a potent histamine antagonist. Trimeprazine possesses sedative properties, and is active in suppressing apomorphine induced vomiting in the dog. No evidence of teratogenic effect has been demonstrated in animal studies. Indications And Clinical Uses: Pruritus regardless of site or etiology….

Brand Names: PALAFER® Manufacturer: SmithKline Beecham Generic Name: Ferrous Fumarate Use: Anemia Therapy Indications And Clinical Uses Increased iron requirements as in childhood, adolescence, and pregnancy; blood losses, overt or occult. Characterized microcytic hypochromic anemia; faulty iron absorption following gastrectomy; iron loss due to menstruation, sub-clinical iron deficiencies in adolescent girls due to precarious iron balance, and geriatrics. Contraindications Hemosiderosis, hemochromatosis. Iron compounds are also contraindicated in the treatment of…

PALUDRINE® Wyeth-Ayerst Proguanil HCl Antimalarial Action And Clinical Pharmacology: Proguanil is metabolized in the body to the antimalarial drug cycloguanil, a triazine derivative, which inhibits plasmodial dihydrofolate reductase thus indirectly inhibiting synthesis of nucleic acids in the parasite. Proguanil, like pyrimethamine, is active against pre-erythrocytic forms and is a slow blood schizontocide. It also has some sporonticidal activity, rendering the gametocytes noninfective to the mosquito vector. Pharmacokinetics: Proguanil is well…

PACIS™ Faulding Bacillus Calmette-Guerin (BCG), substrain Montreal Antineoplastic Action And Clinical Pharmacology: PACIS (Bacillus Calmette-Guerin (BCG), substrain Montreal) promotes a local inflammatory reaction with histiocytic and leukocytic infiltration in the urinary bladder. The local inflammatory effects are associated with an apparent elimination or reduction of superficial cancerous lesions of the urinary bladder. The exact mechanism by which this is accomplished is unknown. Indications And Clinical Uses: For intravesical use in…

PYRIDIUM® Parke-Davis Phenazopyridine HCl Urinary Analgesic Action And Clinical Pharmacology: Phenazopyridine is excreted in the urine where it exerts a topical analgesic effect on the mucosa of the urinary tract. This action helps to relieve pain, burning, urgency and frequency. The precise mechanism of action is unknown. Pharmacokinetics: The pharmacokinetic properties of phenazopyridine have not been determined. Phenazopyridine and its metabolites are rapidly excreted by the kidneys. In a small…

PALAFER® CF SmithKline Beecham Ferrous Fumarate Compound Prenatal Supplement Indications And Clinical Uses: For the treatment of hypochromic anemia and avitaminosis C and to prevent megaloblastic anemia of pregnancy due to folic acid depletion. Contra-Indications: Hemosiderosis, hemochromatosis. Iron compounds are also contraindicated in the treatment of hemolytic anemias unless an iron-deficient state also exists, since storage of iron with a possible exogenous hemosiderosis can result. Precautions: Where anemia exists, its…

PACLITAXEL INJECTION Boehringer Ingelheim Antineoplastic Caution: Paclitaxel is a toxic product and should be administered only by or under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel injection should be pre-treated using corticosteroids, antihistamines, and H2 antagonists (for example dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). All clinical studies referred to in this product monograph were conducted…

PURIFIED PROTEIN DERIVATIVE Connaught PPD-B (Mantoux) Diagnostic Antigen Indications And Clinical Uses: If there is reason to believe that an individual is infected with a mycobacterium other than M. tuberculosis var. hominis, as an added diagnostic procedure, PPD-B (Mantoux), 0.05 g per test dose may be injected using Tuberculin PPD (Mantoux), 5 TU (bioequivalent) per test dose, as a control. Injections are usually made in the same forearm not less…