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PHYLLOCONTIN® PHYLLOCONTIN®-350 Purdue Frederick Aminophylline Bronchodilator Action And Clinical Pharmacology: Aminophylline is the ethylenediamine salt of theophylline. The pharmacodynamics of Phyllocontin and Phyllocontin-350 tablets are a function of theophylline blood levels. Theophylline is a xanthine structurally related to theobromine and caffeine. As with other xanthine derivatives, the precise mechanism of action of theophylline has not been determined. Theophylline stimulates the CNS and skeletal muscles, stimulates cardiac muscle, relaxes certain smooth…

PIPORTIL L4® Rh´ne-Poulenc Rorer Pipotiazine Palmitate Antipsychotic Action And Clinical Pharmacology: Pipotiazine palmitate is the palmitic ester of pipotiazine, a piperidine phenothiazine with antipsychotic properties and weak sedative activity with prolonged duration of action. The onset of action appears usually within the first 2 to 3 days after injection and the effects of the drug on psychotic symptoms are significant within 1 week. Improvement in symptomatology lasts from 3 to…

PIPRACIL® Wyeth-Ayerst Piperacillin Sodium Antibiotic Action And Clinical Pharmacology: Piperacillin is a third-generation, broad-spectrum, semisynthetic penicillin. Piperacillin is bactericidal and exerts its antibacterial action by inhibiting both septum and cell wall synthesis in the bacterial cell. The bactericidal action of b-lactam antibiotics is related to their ability to reach and bind target proteins, the penicillin sensitive enzymes within the cytoplasmic membranes of the bacteria. These enzymes are involved in reactions…

PLAQUENIL® Sanofi Hydroxychloroquine Sulfate Anti-inflammatory – Antimalarial Action And Clinical Pharmacology: Hydroxychloroquine has been beneficial for a high percentage of patients with rheumatoid arthritis and lupus erythematosus, especially chronic discoid lupus. The exact mode of action in controlling these diseases is unknown. The action of this compound against malarial parasites is similar to that of chloroquine phosphate. Indications And Clinical Uses: For the treatment of rheumatoid arthritis, and discoid and…

pHisoHex® Sanofi Hexachlorophene Antibacterial – Skin Cleanser Description: pHisoHex is an antibacterial sudsing emulsion. It contains entsufon (sodium octylphenoxyethoxyethyl ether sulfonate), lanolin cholesterols, petrolatum and 3% hexachlorophene on a total weight basis. It is a colloidal dispersion of the active ingredients in a stable emulsion. Entsufon is a synthetic detergent which is effective in many kinds of water – hard or soft, cold or hot – and under acid as…

PHOSPHATE-NOVARTIS Novartis Pharmaceuticals Sodium Acid Phosphate Hypercalciuria – Electrolyte Replenisher Indications And Clinical Uses: Hypercalciuria, electrolyte replenisher. Contra-Indications: Do not use this medication if hyperphosphatemia is present or in the presence of severe impairment of renal function (less than 30% of normal). Manufacturers’ Warnings In Clinical States: Use carefully in patients with cardiac disease treated with digitalis and in conditions where high potassium concentration may be encountered such as: adrenal…

PHOSPHATES SOLUTION Pharmascience Sodium Phosphates Laxative Action And Clinical Pharmacology: Depending on dosage, sodium phosphates oral solution is useful as a laxative in the relief of constipation, or as a bowel evacuant for a variety of diagnostic, surgical and therapeutic indications. Dibasic sodium phosphate and monobasic sodium phosphate are poorly absorbed from the gastrointestinal tract and retain water in the lumen of the intestine. When administered orally, they produce a…

PHOTOFRIN® Ligand Porfimer Sodium Antineoplastic Photosensitizing Agent Action And Clinical Pharmacology: Pharmacodynamics: The cytotoxic and antitumor actions of porfimer sodium are light and oxygen dependent. Photodynamic therapy (PDT) with porfimer sodium is a 2 stage process. The first stage is the i.v. injection of porfimer sodium. Clearance from a variety of tissues occurs over 40 to 72 hours; but tumor, skin, and organs of the reticuloendothelial system (including liver and…

PHENERGAN® Preparations Novartis Consumer Health Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies:…

PHENERGAN® Injectable Rhône-Poulenc Rorer Promethazine HCl Antihistamine Action And Clinical Pharmacology: Promethazine is an antihistamine with sedative, antiemetic and antispasmodic properties. In addition, it exerts local anesthetic effects and potentiates analgesics, anesthetics and other CNS depressants. Indications And Clinical Uses: Allergic reactions: hay fever, urticaria, vasomotor rhinitis, skin allergies, poison ivy, insect bites; for the relief of pruritus due to various dermatologic conditions. Nausea and vomiting of various etiologies: motion…