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TAXOTERE® Rhône-Poulenc Rorer Docetaxel Antineoplastic Caution: Docetaxel concentrate for injection should be administered under the supervision of a physician experienced in the use of antineoplastic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. Docetaxel therapy should not be given to patients with neutrophil counts of less than 1 500 cells/mm Severe hypersensitivity reactions resulting in immediate discontinuations occurred in 0.4% (5…

TAZIDIME® Lilly Ceftazidime Antibiotic Action and Clinical In vitro studies indicate that the bactericidal action of ceftazidime results from inhibition of bacterial cell wall synthesis. Indications And Clinical Uses : For the treatment of infections caused by susceptible strains of the designated organisms in the diseases listed below: Pneumonia caused by P. aeruginosa, H. influenzae (including ampicillin-resistant strains), Klebsiella species, Enterobacter species, P. mirabilis, E. coli, Serratia species, S. pneumoniae…

TAZOCIN® Wyeth-Ayerst Piperacillin Sodium–Tazobactam Sodium Antibiotic–b-lactamase Inhibitor Action and Clinical Tazocin is an injectable antibacterial combination consisting of the semisynthetic antibiotic piperacillin sodium and the b-lactamase inhibitor tazobactam sodium for i.v. administration. Piperacillin exerts bactericidal activity by inhibiting septum formation and cell wall synthesis. In vitro, piperacillin is active against a variety of gram-positive and gram-negative aerobic and anaerobic bacteria. Tazobactam is a b-lactamase inhibitor. Tazobactam, in combination with piperacillin…

TAZORAC™ Allergan Tazarotene Antipsoriasis Antiacne Action and Clinical Tazarotene is a retinoid prodrug which is converted to its active form, M1 (“tazarotenic acid”, or AGN 190299), by rapid de-esterification in most biological systems. “Tazarotenic acid” binds to and regulates gene expression through all three members of the RAR family of retinoid nuclear receptors, RAR a, RAR b, and RAR g, but shows selectivity for RAR b and RAR g.: Psoriasis:…

TASMAR™ Roche Tolcapone Antiparkinsonian – COMT-inhibitor Action And Clinical Pharmacology: Tolcapone is a selective and reversible inhibitor of catechol-O-methyltransferase (COMT). COMT catalyzes the transfer of the methyl group of S-adenosyl-L-methionine to the phenolic group of substrates that contain a catechol structure. Physiological substrates of COMT include dopa, catecholamines (dopamine, norepinephrine, epinephrine) and their hydroxylated metabolites. The function of COMT is the elimination of biologically active catechols and some other hydroxylated…

TAXOL™ Bristol-Myers Squibb Paclitaxel Antineoplastic Agent Caution: Paclitaxel should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Patients receiving paclitaxel should be pretreated with corticosteroids, antihistamines, and H 2 antagonists (such as dexamethasone, diphenhydramine and cimetidine or ranitidine) to minimize hypersensitivity reactions (see Dosage). Severe hypersensitivity reactions characterized by dyspnea and hypotension requiring treatment, angioedema, and generalized urticaria have occurred in patients…

TARGEL Preparations Odan Tar Compound Antipsoriatic Availability And Storage: Targel: Each g contains: liquor carbonis detergens 10% in a water washable gel base. Nonmedicinal ingredients: carbomer, perfume, propylene glycol, purified water and trolamine. Plastic jars of 100 g. Targel S.A.: Each g contains: liquor carbonis detergens 10% and salicylic acid 3% in a water washable gel base. Nonmedicinal ingredients: carbomer, perfume, propylene glycol, purified water and trolamine. Plastic jars of…

TARKA® Knoll Trandolapril – Verapamil HCl Antihypertensive Action And Clinical Pharmacology: Tarka is a formulation containing slow-release verapamil, a phenylalkylamine calcium channel blocker, along with immediate-release trandolapril, an angiotensin converting enzyme (ACE) inhibitor. Verapamil is a calcium channel blocker that exerts its pharmacologic effects by modulating the influx of ionic calcium across the cell membrane of the arterial smooth muscle as well as in conductile and contractile myocardial cells. Verapamil…

TARO-CARBAMAZEPINE Anticonvulsant-Symptomatic Relief of Trigeminal Neuralgia-Antimanic Action and Clinical Pharmacology Carbamazepine has anticonvulsant properties which have been found useful in the treatment of partial seizures (simple or complex) with and without secondary generalization, and generalized tonic-clonic seizures. A mild psychotropic effect has been observed in some patients, which seems related to the effect of carbamazepine in localization-related epilepsies and syndromes.: Clinical Trials: Evidence supporting the efficacy of carbamazepine as an…

TAMOFEN® Rh´ne-Poulenc Rorer Tamoxifen Citrate Antineoplastic Action And Clinical Pharmacology: Tamoxifen is a nonsteroidal agent which has demonstrated potent antiestrogenic properties in animal test systems. The antiestrogenic effects are related to is ability to compete with estrogen for binding sites in target tissues such as breast and uterus. Tamoxifen inhibits the induction of rat mammary carcinoma induced by dimethylbenzanthracene (DMBA) and causes the regression of already established DMBA-induced tumors. In…