Indications And Clinical Uses: Prevention and treatment of deficiency of ascorbic acid. Ascorbic acid is essential for the formation of collagen and intercellular material, and hence for the development of cartilage, bone and teeth, and for wound healing. It influences the formation of hemoglobin, erythrocyte maturation, and certain immunological reactions in the body. The reducing properties of ascorbic acid are useful in the treatment of idiopathic methemoglobinuria. Useful in large doses to acidify urine.
Precautions: Ascorbic acid may affect the activity of other drugs. In acid urine the excretion of weak acids, such as some sulfonamides, is decreased and that of weak bases, such as quinidine, is increased; the clinical significance of these effects is not known. Other possible hazards are interference by large doses with the effects of warfarin and precipitation of crisis in patients with sickle cell anemia.
Large doses of ascorbic acid may give false negative tests in enzyme dip tests for glycosuria and false positive tests when Benedict’s Solution is used as a test for glycosuria.
Adverse Reactions: The most frequently noted adverse effect of large doses of ascorbic acid is diarrhea. Also, acidification of the urine by large amounts of ascorbic acid may cause the precipitation of urate, oxalate, or cystine stones in the urinary tract.
Dosage: Dissolve tablets in a glass of water immediately before use. The minimum human daily requirement of ascorbic acid for an adult is about 30 mg and for infants 5 mg/kg. The minimum protective dose against clinical scurvy is 10 mg daily. These quantities are normally supplied in the diet, but individuals vary greatly in their requirements, and the higher the metabolic rate (as in pregnancy and lactation) the greater the need; more is required in adolescence, pregnancy and lactation, infections, thyrotoxicosis, and postoperative states. For prophylactic purposes, doses of at least double the minimum requirements are advised, while in cases of known deficiency, or where there is excessive excretion, doses of 100 to 500 mg are employed. A daily allowance of 75 mg for a man and 70 mg for a woman, the latter dose being increased to 100 mg in pregnancy and 150 mg during lactation, has been recommended. For the prevention of infantile scurvy, 5 mg of ascorbic acid may be added to the feeds of bottle fed infants. Oral doses of 150 mg twice daily are used in idiopathic methemoglobinuria. Doses of 1 g every 6 hours are used to acidify urine.
Availability And Storage: Each cylindrical, biplane, rough surfaced, effervescent tablet contains: ascorbic acid 1 g. Tablet forms available: Orange [orange color, orange odor and taste; energy: 26.0 kJ (6.2 kcal); sodium: 12.4 mmol (284 mg)]. Nonmedicinal ingredients: acacia, apocarotenal, carrageenan, dextrin, dl-a-tocopherol, flavor, hydogenated vegetable oil, riboflavin, sodium bicarbonate, sodium chloride, sodium saccharin, sucrose and tartaric acid. Lemon: [yellow color, lemon odor and taste; energy: 24.9 kJ (5.9 kcal); sodium: 12.8 mmol (292 mg)]. Nonmedicinal ingredients: citric acid, cornstarch, flavor, riboflavin, sodium bicarbonate, sodium chloride, sodium saccharin, sucrose and tartaric acid.
Gluten-, lactose-, paraben-, sulfite- and tartrazine-free. Tubes of 10, packs of 12. Keep tube tightly closed in a dry place, between 15 to 30°C. Desiccant in the cap harmless if swallowed. (Shown in Product Recognition Section)
REDOXON® Roche Ascorbic Acid Vitamin