Action And Clinical Pharmacology: Vasopressin is a synthetic water-soluble pressor principle identical in sequence to lysine vasopressin.
Vasopressin exerts its antidiuretic action by increasing the reabsorption of water by the renal tubules. The drug can also cause contraction of smooth muscle of the gastrointestinal tract and all parts of the vascular beds, especially the capillaries, small arterioles, and venules, with less effect on the smooth musculature of the large veins.
The direct effect on the contractile elements is neither antagonized by adrenergic blocking agents nor prevented by vascular denervation.
Vasopressin injection USP is intended for i.m. or s.c. injection.
Indications And Clinical Uses: For the prevention or treatment of postoperative abdominal distention, dispelling of gas shadows in abdominal roentgenography and symptomatic control of diabetes insipidus.
Contra-Indications: Should not be used in patients having cardiorenal disease with hypertension, advanced arteriosclerosis, coronary thrombosis, angina pectoris, epilepsy or toxemia of pregnancy. Anaphylaxis or hypersensitivity to the drug or its components are also contraindications.
Chronic nephritis with nitrogen retention may be a contraindication (see Precautions).
Manufacturers’ Warnings In Clinical States: The drug should not be used except with extreme caution in patients with vascular disease, especially disease of the coronary arteries. In such patients even small doses of the drug may precipitate anginal pain and with larger doses, the possibility of myocardial infarction should be considered.
Vasopressin may produce water intoxication. The early signs of drowsiness, listlessness and headaches should be recognized to prevent convulsions and terminal coma.
Precautions: Vasopressin should be used cautiously in the presence of epilepsy, migraine, asthma, heart failure, or any state in which a rapid addition to extracellular water may produce hazard for an already overburdened system.
Chronic nephritis with nitrogen retention contraindicates the use of vasopressin until reasonable nitrogen blood levels have been attained.
Adverse Reactions: Local or systemic allergic reactions may occur in hypersensitive individuals. The following side effects have been reported following the administration of vasopressin: tremor, sweating, vertigo, circumoral pallor, “pounding” in the head, abdominal cramps, passage of gas, nausea, vomiting, urticaria, bronchial constriction.
Anaphylaxis (cardiac arrest and/or shock) has been observed shortly after injection of vasopressin.
Dosage And Administration: Dosage should be individualized: 0.25 to 0.5 mL i.m. or s.c. at intervals of 3 to 4 hours, as required. Children’s dosages in proportion.
Abdominal Distension: Adults, 0.25 to 0.5 mL.
Abdominal Roentgenography: Adults, 0.5 mL given 2 hours and 0.5 hours before exposure of films.
Diabetes Insipidus: The dose by i.m. or s.c. injection is 0.25 to 0.5 mL repeated 2 or 3 times daily as required.
Availability And Storage: Each mL of aqueous solution contains: vasopressin 20 USP pressor units, chlorobutanol 0.5% as a preservative, and sodium chloride 9 mg/mL. The acidity of the solution is adjusted, if necessary to 2.5 to 4.5 with acetic acid. Ampuls of 5 mL, boxes of 1. Keep away from heat.
PRESSYN® Ferring Vasopressin Antidiuretic Agent