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ATROVENT® Inhalation Solution Boehringer Ingelheim Ipratropium Bromide Bronchodilator Action And Clinical Pharmacology: Ipratropium, a quaternary ammonium derivative of atropine, is an anticholinergic drug which has bronchodilator properties. On inhalation, the onset of action is noted within 5 to 15 minutes, with a peak response between 1 and 2 hours, lasting about 2 additional hours, with subsequent decline from the peak. Bronchodilation is still evident 8 hours after inhalation. In acute…

AURALGAN® Whitehall-Robins Antipyrine – Benzocaine Analgesic – Antiphlogistic Indications And Clinical Uses: As an analgesic and decongestant for pain and inflammation in the ear, swimmer’s ear; adjunctive treatment of otitis media. Contra-Indications: Hypersensitivity to any of the components. Precautions: Do not rinse dropper with water. Keep dry. Keep well closed. Dosage: Warm Auralgan slightly and fill ear canal. Saturate cotton plug with Auralgan and insert in ear. Repeat several times…

ATROPINE SULFATE INJECTION USP Astra Atropine Sulfate Parasympatholytic Action And Clinical Pharmacology: Atropine is commonly classified as an anticholinergic or antiparasympathetic (parasympatholytic) drug. More precisely, however, it is termed an antimuscarinic agent since it antagonizes the muscarine-like actions of acetylcholine and other choline esters. Atropine inhibits the muscarinic actions of acetylcholine on structures innervated by postganglionic cholinergic nerves, and on smooth muscles which respond to endogenous acetylcholine but are not…

ATRACURIUM BESYLATE INJECTION Faulding I.V. Skeletal Neuromuscular Blocking Agent Action And Clinical Pharmacology: Atracurium is a nondepolarizing, intermediate-duration, skeletal neuromuscular blocking agent. Nondepolarizing agents antagonize the neurotransmitter action of acetylcholine by binding competitively to cholinergic receptor sites on the motor endplate. This antagonism is inhibited, and neuromuscular block reversed by acetylcholinesterase inhibitors such as neostigmine, edrophonium and pyridostigmine. The duration of neuromuscular blockade produced by atracurium is approximately one-third to…

ATGAM® Pharmacia & Upjohn Lymphocyte Immune Globulin – Anti-Thymocyte Globulin (Equine) Immunosuppressant Action And Clinical Pharmacology: Atgam is the purified, concentrated, and sterile gamma globulin, primarily monomeric IgG, from hyperimmune plasma of horses immunized with human thymus lymphocytes. Atgam is a lymphocyte-selective immunosuppressant as is demonstrated by its ability to reduce the number of circulating, thymus-dependent lymphocytes that form rosettes with sheep erythrocytes. This antilymphocyte effect is believed to reflect…

ASCOFER® Desbergers Ferrous Ascorbate Hematinic Indications And Clinical Uses: Ferrous ascorbate, a synthetic molecule of ascorbic acid and iron, is indicated in the treatment of iron deficiency anemia. Contra-Indications: Hemosiderosis, hemochromatosis, hemolytic anemia. Precautions: Oral iron preparations may aggravate existing peptic ulcer, regional enteritis and ulcerative colitis. Iron compounds taken orally can impair the absorption of tetracycline antibiotics. Antacids given concomitantly with iron compounds decrease iron absorption. Adverse Reactions: The…