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AREDIA® Novartis Pharmaceuticals Pamidronate Disodium Bone Metabolism Regulator Action And Clinical Pharmacology: Pamidronate belongs to a class of bisphosphonates (previously termed diphosphonate), which inhibit bone resorption. The therapeutic activity of pamidronate is attributable to its potent anti-osteoclastic activity on bone. In animal studies, at therapeutic doses, pamidronate inhibits bone resorption apparently without inhibiting bone formation and mineralization. The predominant means by which pamidronate reduces bone turnover both in vitro and…

AQUACORT® Spectropharm Dermatology Hydrocortisone Topical Corticosteroid Action And Clinical Pharmacology: Topical corticosteroids are synthetic derivatives of cortisone which are effective when applied locally to control many types of inflammatory, allergic and pruritic dermatoses. They are thought to act by controlling the rate of synthesis of proteins. The primary action of the corticosteroid is to interfere with the synthesis of arachidonic acid by inhibiting the phospholipase A2 synthesis. The overall effect…

AQUAPHOR® Smith & Nephew Petrolatum Dermatological Base Indications And Clinical Uses: A neutral, anhydrous base for compounding smooth, stable emulsions; highly miscible with both aqueous solutions and other oil-based substances. For severely dry skin. Also helps promote healing of minor skin irritations. Precautions: For external use only. Avoid contact with eyes. If this occurs, rinse thoroughly with water. If rash or irritation occurs or worsens, discontinue use and consult a…

APO®-DOMPERIDONE Apotex Domperidone Maleate Modifier of Upper Gastrointestinal Motility Action And Clinical Pharmacology: Domperidone is a peripheral dopamine antagonist structurally related to the butyrophenones with antiemetic and gastroprokinetic properties. Domperidone effectively increases esophageal peristalsis and lower esophageal sphincter pressure (LESP), increases gastric motility and peristalsis, enhances gastroduodenal coordination and consequently facilitates gastric emptying and decreases small bowel transit time. The mechanism of action of domperidone is related to its peripheral…

APO®-CROMOLYN Apotex Sodium Cromoglycate Seasonal Rhinitis Prophylaxis Action And Clinical Pharmacology: In the immediate allergic reaction (Type I) the union of antigen with reaginic antibody leads to the formation and release of spasmogens and other mediators of the anaphylactic reaction. Sodium cromoglycate appears to block a step in the chain of events triggered by this union. This property accounts for the prophylactic rather than symptomatic approach to the management of…

APO®-CROMOLYN STERULES Apotex Cromolyn Sodium Asthma Prophylaxis Action And Clinical Pharmacology: In vitro and in vivo animal studies have shown that cromolyn sodium inhibits sensitized mast cell degranulation which occurs after exposure to specific antigens. It acts by inhibiting the release of mediators from mast cells. Studies show that cromolyn sodium indirectly blocks calcium ions from entering the mast cell, thereby preventing mediator release. Cromolyn sodium inhibits both the immediate…

ANUSOL® ANUSOL® PLUS Warner-Lambert Consumer Healthcare Zinc Sulfate Monohydrate Pramoxine HCl – Zinc Sulfate Monohydrate Anorectal Therapy Indications And Clinical Uses: Symptomatic relief of pain and discomfort as in: external and internal hemorrhoids, proctitis, papillitis, cryptitis, fissures, incomplete fistulas and relief of local pain following anorectal surgery. Contra-Indications: History of sensitivity to any component. Precautions: In case of rectal bleeding, consult physician promptly. Adverse Reactions: An occasional patient may experience…

ANUSOL® ANUSOL® PLUS Warner-Lambert Consumer Healthcare Zinc Sulfate Monohydrate Pramoxine HCl – Zinc Sulfate Monohydrate Anorectal Therapy Indications And Clinical Uses: Symptomatic relief of pain and discomfort as in: external and internal hemorrhoids, proctitis, papillitis, cryptitis, fissures, incomplete fistulas and relief of local pain following anorectal surgery. Contra-Indications: History of sensitivity to any component. Precautions: In case of rectal bleeding, consult physician promptly. Adverse Reactions: An occasional patient may experience…

  ANTIPHLOGISTINE RUB A-535 Carter Horner Methyl Salicylate – Camphor – Menthol – Eucalyptus Oil Topical Analgesic Indications And Clinical Uses: External counterirritant cream for temporary pain relief of stiff and sore muscles, backache, strains, arthritic and rheumatic pain, sciatica, lumbago and bursitis. Contra-Indications: Salicylate hypersensitivity. Precautions: For external use only. Do not apply to wounds or damaged skin and avoid contact with eyes and mucous membranes. Discontinue use if…

ANTURAN® Novartis Pharmaceuticals Sulfinpyrazone Platelet Inhibitory Agent – Uricosuric Agent – Prophylactic Agent for Reduction of Mortality Post-myocardial Infarction Action And Clinical Pharmacology: Sulfinpyrazone inhibits thrombotic processes that are associated with platelet adhesion, aggregation and reduced platelet survival. Sulfinpyrazone reduces serum urate levels, prevents formation of new tophi, and promotes resorption of existing tophi by increasing clearance of uric acid and water through the kidneys. Sulfinpyrazone has been shown to…