BLENOXANE® Bristol Bleomycin Sulfate Antineoplastic – Antibiotic Action And Clinical Pharmacology: Although the exact mechanism of action of bleomycin is unknown, available evidence indicates that the main mode of action is inhibition of DNA synthesis with some evidence of inhibition of RNA and protein synthesis. The major route of excretion of bleomycin is the kidney, with 60 to 70% of an administered dose recovered in the urine as active bleomycin….
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Blenoxane (Bleomycin Sulfate)
(Pharmaceutical)Bleomycin Sulfate USP
(Pharmaceutical)BLEOMYCIN SULFATE USP Faulding Antineoplastic Action And Clinical Pharmacology: Experiments with isolated DNA have shown that bleomycin binds to the DNA molecule and cleaves it. This results in the inhibition of DNA synthesis. There is also evidence of lesser inhibition of RNA and protein synthesis. Bleomycin exhibits a wide spectrum of in vitro and in vivo activity. It demonstrates inhibition of DNA synthesis in E. coli, B. subtilis, Ehrlich ascites…
Biolon (Sodium Hyaluronate)
(Pharmaceutical)BIOLON Ophtapharma Sodium Hyaluronate Ophthalmosurgical Aid Action And Clinical Pharmacology: Sodium hyaluronate is a physiological material found in both animal and human tissues. It is a polysaccharide consisting of a repeating disaccharide of N-acetylglucosamine and sodium glucuronate, linked by alternating b-1,3 and b-1,4 glycosidic bonds. Chemically identical in all species, hyaluronate can be found in the vitreous and aqueous humor of the eye, in synovial fluid, in skin and in…
Biltricide (Praziquantel)
(Pharmaceutical)BILTRICIDE® Bayer Praziquantel Anthelmintic Action And Clinical Pharmacology: Mechanism of Action: Praziquantel induces a rapid contraction of schistosomes by a specific effect on the permeability of the cell membrane. The drug further causes vacuolization and disintegration of the schistosome tegument. The effect is more marked on adult worms compared to young worms. An increased calcium influx may play an important role. Secondary effects are inhibition of glucose uptake, lowering of…
Bionet (Benzocaine – Bicetonium)
(Pharmaceutical)BIONET® Carter Horner Benzocaine – Bicetonium Local Anti-infective – Analgesic Indications And Clinical Uses: The symptomatic treatment of mild infection and relief of pain in gum, pharyngeal, tonsillar and other oral disorders such as aphthous ulcers, stomatitis and gingivitis. May also be used postoperatively in tonsillectomy, dental surgery and tooth extraction. Contra-Indications: Benzocaine sensitivity. Precautions: Severe or persistent sore throat accompanied by high fever, headache, nausea and vomiting may be…
Biquin Durules
(Pharmaceutical)BIQUIN DURULES® Astra Controlled Release Quinidine Bisulfate Antiarrhythmic Agent Action And Clinical Pharmacology: Quinidine is a class IA antiarrhythmic agent according to the modified Vaughan-Williams classification. Quinidine is considered a myocardial depressant. Direct actions on the heart include: decreased myocardial excitability; prolongation of the atrial, ventricular and Purkinje refractory periods; decreased atrial, Purkinje and ventricular conduction velocities; substantially decreased firing rate of cardiac Purkinje fibres by direct action; decreased myocardial…
Bicnu (Carmustine)
(Pharmaceutical)BiCNU® Bristol Carmustine Antineoplastic Agent Action And Clinical Pharmacology: Carmustine alkylates DNA and RNA and has been shown to inhibit several enzymes by carbamoylation of amino acids in proteins. In a series of in vivo and in vitro experiments with formate 4, adenine-8-4 and DL-leucine-4,5-, Wheeler and Bowdon obtained results indicating that carmustine interferes with the de novo synthesis of purine nucleotides and with the conversion of purine nucleotides to…
Betagan (Levobunolol)
(Pharmaceutical)BETAGAN® Allergan Levobunolol HCl Glaucoma Therapy Action And Clinical Pharmacology: Levobunolol is a noncardioselective beta- adrenoceptor antagonist, equipotent at both beta1 and beta2 receptors. Levobunolol is approximately 60 times more potent than the dextro isomer in its beta-blocking activity, yet equipotent in its potential for direct myocardial depression. Accordingly, the levo isomer, levobunolol, is used. Levobunolol does not have significant local anesthetic (membrane-stabilizing) effect or intrinsic sympathomimetic activity. Beta-adrenergic receptor…
Berotec Inhalation Solution (Fenoterol HBr)
(Pharmaceutical)BEROTEC® Inhalation Solution Boehringer Ingelheim Fenoterol HBr Bronchodilator Action And Clinical Pharmacology: The bronchodilating effect of fenoterol is produced primarily by stimulation of b2-receptors in the bronchial smooth muscles. The effect has been measured by means of spirometry (FEV1, FVC, MMFR), peak flow rates, flow volume curves, airway resistance (plethysmography) and oscillation mechanics. Fenoterol, when administered by inhalation, exerts a significant increase in pulmonary function 5 minutes after administration and…
Bactroban (Mupirocin)
(Pharmaceutical)BACTROBAN® SmithKline Beecham Mupirocin Topical Antibiotic Action And Clinical Pharmacology: Mupirocin exerts a bactericidal action against sensitive organisms by inhibiting bacterial protein synthesis. It reversibly and specifically binds to bacterial isoleucyl transfer-RNA synthetase Indications And Clinical Uses: For the topical treatment of the following when caused by sensitive strains of staphylococcus and streptococcus species: impetigo, superficially infected dermatoses, lesions which are moist and weeping. For abrasions, minor cuts and wounds,…