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CILOXAN® Alcon Ciprofloxacin HCl Antibacterial Agent Action And Clinical Pharmacology: The bactericidal action of ciprofloxacin results from inhibition of the enzyme, DNA gyrase, which is required for the synthesis of bacterial DNA. Pharmacokinetics: Topically applied ciprofloxacin ophthalmic solution is absorbed systemically with ciprofloxacin plasma concentrations approaching steady state at the end of dosing each day. Ciprofloxacin plasma concentrations following a routine ophthalmic treatment regimen were in the range of nonquantifiable…

CIPRO® CIPRO® I.V. CIPRO® Oral Suspension Bayer Ciprofloxacin HCl Ciprofloxacin Ciprofloxacin Antibacterial Action And Clinical Pharmacology: Ciprofloxacin, a synthetic fluoroquinolone, has a bactericidal mode of action. This action is achieved through inhibition of DNA gyrase, an essential component of the bacterial DNA replication system. Inhibition of the alpha subunit of the DNA gyrase blocks the resealing of the nicks on the DNA strands induced by this alpha subunit, leading to…

CISPLATIN INJECTION Faulding Antineoplastic Action And Clinical Pharmacology: Cisplatin is thought to act by producing inter-strand and intra-strand cross-links of cellular DNA in a similar manner to bifunctional alkylating agents. It does not appear to be cell-cycle specific. Using radioactive platinum, a high uptake of the drug was found in kidneys, liver and intestines with poor penetration of the CNS. An initial plasma half-life of 25 to 49 minutes and…

CHYMODIACTIN® Knoll Chymopapain Proteolytic Enzyme Action And Clinical Pharmacology: Chymopapain for intradiscal injection is injected into the herniated nucleus pulposus of the lumbar intervertabral disc resulting in rapid hydrolysis of the noncollagenous polypeptides or proteins that maintain the tertiary structure of the chondromucoprotein. This lessens the intradiscal osmotic activity, thereby decreasing fluid absorption and reducing intradiscal pressure. The foregoing mechanism of action is based on animal in vitro and in…

CICATRIN® Glaxo Wellcome Bacitracin – Neomycin Sulfate – Amino Acids Antibiotic – Tissue Healant Indications And Clinical Uses: As a prophylactic or treatment and healing agent for surface wounds, minor burns, and stasis ulcers. Not recommended for the treatment of superficial fungal infections. The use of the powder does not exclude concomitant systemic therapy with antibiotics where appropriate. Contra-Indications: Patients who have demonstrated allergic hypersensitivity to the product or any…

CANTHACUR® Pharmascience Cantharidin Vesicant Indications And Clinical Uses: For the topical use of removal of benign epithelial growths such as warts (verruca vulgaris) or molluscum contagiosum. Because of the absence of scarring, cantharidin is useful for treating exposed areas where cosmetic results are important. Painless application and the absence of instruments makes it especially useful for treating children. Contra-Indications: Hypersensitivity to the ingredients. Avoid alcoholic beverages for several hours after…

Indications And Clinical Uses: For the topical use of removal of benign epithelial growths such as warts (verruca vulgaris), especially plantar, mosaic, periungual, and molluscum contagiosum. Recommended for resistant and heavily keratinized warts. Because of the absence of scarring, the mixture is useful for treating exposed areas where cosmetic results are important. Contraindications: Hypersensitivity to the ingredients. Avoid alcoholic beverages for several hours after treatment. Precautions: Canthacur-PS is a potent…

CALCIUM-SANDOZ® Novartis Consumer Health Calcium Preparations Calcium Therapy Indications And Clinical Uses: As a dietary supplement where calcium intake may be inadequate: childhood and adolescence, pregnancy and lactation, postmenopausal females and in the aged. In the treatment of calcium deficiency states which may occur in diseases such as: tetany of the newborn (as a supplement to parenterally administered calcium), hypoparathyroidism (acute and chronic), pseudo-hypoparathyroidism, postmenopausal and senile osteoporosis, rickets and…

CALCIMAR® Rhône-Poulenc Rorer Calcitonin Salmon Paget’s Disease Therapy – Hypercalcemia Treatment Action And Clinical Pharmacology: Calcitonin is a group of polypeptide hormones secreted by the thyroid gland in mammals and by the ultimobranchial gland of birds and fish. It is of physiological importance in the regulation of calcium metabolism in certain animal species, and may also have physiological importance in certain extra skeletal systems (e.g., gastrointestinal and renal function). Only…

CALCIUM SALTS: ORAL General Monograph Calcium Therapy Pharmacology: Calcium is the most abundant mineral in the human body and is essential for maintaining the functional integrity of nervous and musculoskeletal systems as well as cell membrane and capillary permeability. The majority (99%) of body calcium is contained in bone with the remainder equally distributed between intra- and extracellular fluids. Calcium is an activator in many enzymatic reactions and is necessary…