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ACTIVASE® rt-PA Roche Alteplase Fibrinolytic Agent Action And Clinical Pharmacology: Alteplase is a serine protease which has the property of fibrin-enhanced conversion of plasminogen to plasmin. It produces minimal conversion of plasminogen in the absence of fibrin; and when introduced into the systemic circulation, alteplase binds to fibrin in a thrombus and converts the entrapped plasminogen to plasmin. This initiates local fibrinolysis with minimal systemic effects. Following administration of alteplase…

ACULAR® Allergan Ketorolac Tromethamine Topical Anti-inflammatory Action And Clinical Pharmacology: Ketorolac is a nonsteroidal, anti-inflammatory agent demonstrating analgesic and anti-inflammatory activity. At concentrations of 0.02 to 0.5%, ketorolac solution did not irritate the eyes of rats, dogs and monkeys. Up to 4% concentrations were nonirritating in albino rabbits. Ketorolac has demonstrated anti-inflammatory activity when applied topically in several animal models of ocular inflammation. The compound significantly inhibited the inflammatory response…

ACYCLOVIR SODIUM FOR INJECTION Novopharm Antiviral Action And Clinical Pharmacology: Acyclovir, a synthetic acyclic purine nucleoside analog, is a substrate with a high degree of specificity for herpes simplex and varicella-zoster-specified thymidine kinase. Acyclovir is a poor substrate for host cell-specified thymidine kinase. Herpes simplex and varicella-zoster-specified thymidine kinase transform acyclovir to its monophosphate which is then transformed by a number of cellular enzymes to acyclovir diphosphate and acyclovir triphosphate….

ACEL-P™ Wyeth-Ayerst Acellular Pertussis Vaccine Adsorbed Active Immunizing Agent Action And Clinical Pharmacology: Pertussis disease (whooping cough) is caused by a gram-negative coccobacillus, B. pertussis. Acellular pertussis vaccine adsorbed is an acellular pertussis vaccine indicated for primary immunization against disease caused by B. pertussis. Pertussis (whooping cough) has 3 typical stages (catarrhal, paroxysmal, and convalescent). The second phase is characterized by severe paroxysmal coughing that persists for weeks. The disease…

  ACNOMEL® Chattem Resorcinol – Sulfur Compound Acne Therapy Indications And Clinical Uses: Treatment of acne: basic topical medication for acne. The tinted cream may be used by patients who desire a medicated preparation to mask lesions. Contra-Indications: Should not be applied to diffuse, acutely inflamed areas. Keep out of eyes and off eyelids. Precautions: Moderate erythema and scaling are normal and expected results of therapy. However, should these reactions…

ACNOMEL® Acne Mask Chattem Salicylic Acid Acne Therapy Indications And Clinical Uses: For treatment of acne. Precautions: Avoid contact with eyes. Dosage: Splash face with warm water. Apply the acne mask over entire face, avoiding eyes. Leave on as a mask for 10 minutes. Rinse off with warm water. Use once or twice weekly. Availability And Storage: Each mL contains: salicylic acid 1.5% in cream base with 100% natural clays….

ACCUPRIL™ Parke-Davis Quinapril HCl Angiotensin Converting Enzyme Inhibitor Action And Clinical Pharmacology: Quinapril is a nonpeptide, nonsulphydryl inhibitor of angiotensin converting enzyme (ACE), which is used in the treatment of hypertension. Angiotensin converting enzyme (ACE) is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor angiotensin II. After absorption, quinapril is rapidly de-esterified to quinaprilat (quinapril diacid), its principal active metabolite. Its primary mode of action…

ACCURETIC™ Parke-Davis Quinapril HCl – Hydrochlorothiazide Angiotensin-Converting Enzyme Inhibitor – Diuretic Action And Clinical Pharmacology: Accuretic is a fixed-combination tablet which combines the antihypertensive actions of an angiotensin-converting enzyme (ACE) inhibitor, quinapril HCl, and a diuretic, hydrochlorothiazide. In clinical studies, administration of this combination produced greater reductions in blood pressure than the single agents given alone. Pharmacokinetics and Metabolism: Quinapril: Following oral administration of quinapril, peak plasma concentrations of quinapril…

ACCUTANE™ ROCHE® Roche Isotretinoin Acne Therapy Action And Clinical Pharmacology: The mechanism of action of isotretinoin is unknown. Vitamin A is important for functional integrity of the skin and is known to affect the keratinization process. In acne patients, improvement occurs in association with a reduction in sebum secretion. The decrease in sebum secretion is temporary and is related to either the dose or duration of isotretinoin administration and reflects…

ACE INHIBITORS General Monograph, Benazepril Captopril Cilazapril Enalapril Enalaprilat Fosinopril Lisinopril Perindopril Quinapril Ramipril Trandolapril Angiotensin Converting Enzyme Inhibitor, Action And Clinical Pharmacology: The renin-angiotensin system is a complex neuroendocrine system involved in the regulation of hemodynamics and water and electrolyte balance. When released from the kidney in response to a decrease in blood volume, renal perfusion pressure or plasma sodium concentration, renin acts on its substrate, angiotensinogen, to form…