ZOSTRIX® H.P. Medicis Capsaicin Neuralgia Therapy   Action And Clinical Pharmacology: Current evidence suggests that capsaicin works by its action on a pain transmitting compound called substance P. Capsaicin causes substance P to leave the nerve endings. With a lower amount of substance P in the nerve endings, pain impulses cannot be transmitted to the brain. tag_IndicationsIndications Indications: For the relief of neuralgias (pain from nerves near the surface of the skin) such as painful diabetic neuropathy, postsurgical pain and temporary relief of arthritic pain in rheumatoid and osteoarthritis. Warnings: Avoid contact with eyes. Do not apply to wounds or damaged skin. Do not bandage. If condition worsens or does not improve after 28 days, discontinue use of this product and consult your physician. Keep this and all drugs out of the reach of children. Dosage: Adults and children 2 years of age and older: Apply to affected area 3 to 4 times daily. A transient burning sensation related to the action of the product may occur over the first several days of use. Application schedules less than 3 times a day may not provide optimum pain relief and the burning sensation may persist. Unless treating hands, wash hands immediately after application, avoiding areas where drug is applied. Availability And Storage: Each tube of cream contains: capsaicin 0.075% in an emollient base. Tubes of 60 g.